童胜，男，博士，副教授。主要从事微生物蛋白资源挖掘与利用及药用功能成分生物制造研究。先后主持国家自然科学青年基金、国家重点研发计划青年科学家项目（任务）、国家重点研发计划项目（子课题）、中国博士后科学基金等5项科研任务，作为第一/共一作者在Plant Biotechnology Journal、PLoS Pathogens、Journal of Agricultural and Food Chemistry、Synthetic and Systems Biotechnology等国际期刊发表SCI论文10篇，申请国家专利12项，已授权8项，担任Microbiology spectrum等杂志的审稿工作。
主要经历
2024.05-至今 西南大学必赢nn699net副教授
2021.04-2024.04 中国科学院天津工业生物技术研究所博士后
2013.09-2020.12 西南大学 生物技术中心博士
2009.09-2013.06 河南农业大学农学院学士
发表论文
(1)Tong, S#.,Chen, W#.,Hong,R.,Zhang,Y.,Sun,Y.,Wang, Q.,&Li, D. (2024).Efficient mycoprotein production with low CO2emissions through metabolic engineering and fermentation optimization inFusarium venenatum.Journal of Agricultural and Food Chemistry, 71 (1),604-612.
(2)Tong, S#.,An, K#., Chen, W., Chai, M., Sun, Y., Wang, Q., & Li, D. (2023). Identification of neutral genome integration sites with high expression and high integration efficiency inFusarium venenatumTB01.Synthetic and Systems Biotechnology, 8 (1), 141-147.
(3)Tong, S#.,An, K#., Chen, W., Zhou, W., Sun, Y., Wang, Q., & Li, D. (2022). Evasion of Cas9 toxicity to develop an efficient genome editing system and its application to increase ethanol yield inFusarium venenatumTB01. Applied Microbiology and Biotechnology, 106, 6583-6593.
(4)Tong, S.,Zhao, L., Zhu, D., Chen, W., Chen, L., & Li, D. (2022). From formic acid to single-cell protein: genome-scale revealing the metabolic network ofParacoccus communisMA5. Bioresources and Bioprocessing, 9, 55.
(5)Tong, S.,An, K., Zhou, W., Chen, W., Sun, Y., Wang, Q., & Li, D. (2022). Establishment of high-efciency screening system for gene deletion inFusarium venenatumTB01. Journal of Fungi, 8 (2), 169.
(6)Tong, S.,Yuan, M., Liu, Y., Li, X., Jin, D., Cheng, X., Lin, D., Ling, H., Yang, D., Wang, Y., Mao, A., Pei, Y., & Fan,Y. (2020). Ergosterol-targeting fusion antifungal peptide significantly increases the Verticillium wilt resistance of cotton. Plant Biotechnology Journal, 19, 926-936.
(7)Tong, S#.,Li, M#., Keyhani, N.O., Liu, Y., Yuan, M., Lin, D., Jin, D., Li, X., Pei, Y., & Fan, Y. (2020). Characterization of a fungal competition factor: production of a conidial cell-wall associated antifungal peptide. PLoS Pathogens, 16(4), e1008518.
(8)Chen, L#.,Tong, S#.,Liu,W.,Zhang,Y.,Chen,W.,Li, Y.,Li, D.,Yan,B., &Chen, G. (2023).Electroporation-induced mutation and transcriptome analysis for high DHA production inSchizochytrium limacinumGCD2032. Algal Research,76, 103297.
(9) Zhou, W#.,Tong, S#., Farrukh, R.A.,Chen, W., Cai, J., &Li, D. (2023). Heterologous expression and biochemical characterization of a thermostable endoglucanase (MtEG5-1) fromMyceliophthora thermophila. Fermentation, 9(5), 462.
(10) Li, J#.,Tong, S#., Farrukh, R.A.,Habiba, K., Chen, K., Zhao, X., Cai, J., &Li, D. (2023). Enhance the activity of self-inducible promoter inEscherichia colithrough saturation mutation and high throughput screening. Fermentation, 9(5), 468.
(11)Zhai, Y.,Tong, S.,Chen, L., Zhang, Y., Amin, F.R., Khalid, H., Liu, F., Duan, Y.,Chen, W., Chen, G., & Li, D. (2024). The enhancement of energy supply in syngas-fermenting microorganisms. Environmental Research, 252 (2), 118813.
(12) Zhu, X., Meng, C., Sun, F., Wei, Z., Chen, L., Chen, W.,Tong, S.,Du, H., Gao, J., Ren, J., Li, D., & Gao, Z. (2022). Sustainable production of astaxanthin in microorganisms: the past, present, and future. Critical Reviews in Food Science and Nutrition, 2, 1-17.
(13) Zhu, S., Feng, X., Keyhani, N.O., Liu, Y., Jin, D.,Tong, S.,Pei, Y.,& Fan, Y. (2021). Manipulation of host ecdysteroid hormone levels facilitates infection by the fungal insect pathogen,Metarhizium rileyi. Environmental Microbiology, 23(9), 5087-5101.
(14) Wang, J., Ma, Y., Liu, Y.,Tong, S.,Zhu, S., Jin, D., Pei, Y., & Fan, Y. (2020). A polyketide synthase, Bbpksp, contributes to conidial cell wall structure and UV tolerance inBeauveria bassiana. Journal of Invertebrate Pathology, 169, 107280.
(15) Liu, Y., Li, Y.,Tong, S.,Yuan, M., Wang, X., Wang, J., & Fan, Y. (2020) Expression of aBeauveria bassianachitosanase (BbCSN-1) inPichia pastorisand enzymatic analysis of the recombinant protein. Protein Expression and Purification, 166, 105519.
(16) Fan, Y., Liu, X., Keyhani, N.O., Tang, G.R., Pei, Y., Zhang, W., &Tong, S.(2017). The regulatory cascade and biological activity ofBeauveria bassianaoosporein that limits bacterial growth after host death. Proc Natl Acad Sci U S A, 114(9), E1578-E1586.
主持项目
国家自然科学青年基金(32300052, 20万,主持, 2024.01-2025.12)
国家重点研发计划青年科学家项目(2023YFD1302400, 70万,任务负责人,2023.12-2028.11)
国家重点研发计划项目(2023YFD1201605, 30万,子课题负责人,2023.12-2027.11)
中国博士后面上科学基金(2022M713329, 8万,主持, 2022.08-2023.12).
天津市合成生物技术创新能力提升行动(TSBICIP-CXRC-050, 100万,主持, 2021.06-2024.04).
申请专利
(1)童胜;李德茂;陈吴西;马延和;王钦宏;孙媛霞.丙酮酸脱羧酶基因FvPDC6及其在提高威尼斯镰刀菌菌丝蛋白产量中的应用. CN202310893030.9. (已授权)
(2)童胜;李德茂;陈吴西;马延和;王钦宏;孙媛霞.威尼斯镰刀菌糖异生途径阻断菌株及其制备方法和应用. CN202310690496.9.(已受理)
(3)陈吴西;李德茂;童胜;马延和;王钦宏;孙媛霞.提高菌丝蛋白含量的菌丝体生产方法. 202310589073.8. (已受理)
(4)陈利梅;陈吴西;童胜;李德茂.裂殖壶菌GCD2032菌株及其制备方法和应用. 202310580996.7. (已受理)
(5)马延和;童胜;李德茂;安可心;王钦宏;陈吴西;孙媛霞.威尼斯镰刀菌TB01的整合位点及其应用. CN202211384512.3.(已受理)
(6)马延和;童胜;李德茂;王钦宏;陈吴西;孙媛霞.一种来源于威尼斯镰刀菌的启动子及可视化基因敲除筛选方法. CN202210314499.8.(已授权)
(7)马延和;童胜;李德茂;王钦宏;陈吴西;孙媛霞.威尼斯镰刀菌内源U6启动子及其基于CRISPR/Cas9的基因编辑方法. CN202210314506.4.(已授权)
(8)马延和;李德茂;陈吴西;童胜;齐显妮;曾艳;王钦宏;孙媛霞.一种利用糖蜜生产菌丝蛋白的方法. CN202210110282.5.(已授权)
(9)李德茂;黄群;陈吴西;童胜;陈利梅.泛养副球菌菌株MA3、生产方法及其应用. CN202111495478.2.(已授权)
(10)范艳华;刘宇;童胜;李茂莲;袁敏;林冬梅.抗菌肽基因启动子PBbAFP1在改良虫生真菌孢子中的用途. CN201911174360.2.(已授权)
(11)李先碧;裴炎;范艳华;牛国清;肖月华;侯磊;金丹;童胜;林道尧.基于转录因子间的互作关系构建双激素响应启动子的方法. CN201910446843.7.(已授权)
(12)范艳华;童胜;李先碧;金丹;裴炎.一种提高spCEMA对植物病原菌抗性的方法及转基因烟草材料. CN201710353621.1.(已授权)
联系方式
tiantiantongsheng@163.com
