张勇,博士,西南大学必赢nn699net,教授,博士生导师,专注于植物基因组编辑及合成生物学相关教学、科研工作开展了系列研究工作:1)在Nature Plants、Molecular Plant、Nature Communications等期刊发表论文120余篇,Google Scholar引用9700余次,H指数38,得到Science、Nature、Nature Reviews Genetics、Nature Plants等高影响力期刊引用及评述,16篇论文入选ESI高被引论文,6篇论文入选ESI热点论文;2)申请发明专利30项,授权22项,搭建了植物基因组编辑功能元件挖掘、工具库构建及种质创新应用的知识产权链条;3)入选科睿唯安2022年植物与动物科学“全球高被引科学家”,评为四川省学术和技术带头人、四川省有突出贡献的优秀专家;4)主持国家自然科学基金、国家转基因重大专项课题、四川省杰出青年科技人才基金等科研项目;5)受邀在第七届国际作物科学大会(2017)、中国作物学会第十一届代表大会(2019)、中国农业生物技术学会第六次全国代表大会(2021)、中国植物生理与植物分子生物学2023年全国学术年会暨成立六十周年庆祝大会(2023)等会议做专题报告;6)当选中国生物工程学会理事、中国遗传学会基因组编辑分会第一、二届委员、四川省遗传学会第八、九、十届理事会理事及多个省部级重点实验室学术委员会委员。
教育背景
1996年09月—2000年06月,西南(农业)大学,园艺园林学院,园艺学专业,本科
2000年09月—2003年06月,西南(农业)大学,园艺园林学院,果树学专业,硕士
2003年09月—2006年06月,南开大学,必赢nn699net,遗传学专业,博士
工作经历
2023年09月-今, 西南大学, 必赢nn699net,教授
2015年08月-2023年09月, 电子科技大学,生命科学与技术学院,教授
2013年07月-2013年11月, 明尼苏达大学,医学院/基因组工程中心,访问教授
2011年08月-2012年10月, 明尼苏达大学,医学院/基因组工程中心,高级研究员
2010年07月-2011年07月, 明尼苏达大学,医学院/基因组工程中心,博士后
2008年07月-2015年07月, 电子科技大学,生命科学与技术学院,副教授
2007年01月-2010年03月, 四川农业大学,农学院,博士后
2006年06月-2008年06月, 电子科技大学,生命科学与技术学院,讲师
代表性成果文(*通讯作者)
1.Zhong Z, Liu G, Tang Z, Xiang S, Yang L, Huang L, He Y, Fan T, Liu S, Zheng X, Zhang T, Qi Y*, Huang J* andZhang Y*. 2023. Efficient plant genome engineering using a probiotic sourced CRISPR-Cas9 system. Nat Commun, 14: 6102.
2.Tang X andZhang Y*. 2023. Beyond knockouts: fine-tuning regulation of gene expression in plants with CRISPR-Cas-based promoter editing. New Phytol, 239: 868-874.
3.Zhou J, Liu G, Zhao Y, Zhang R, Tang X, Li L, Jia X, Guo Y, Wu Y, Han Y, Bao Y, He Y, Han Q, Yang H, Zheng X, Qi Y*, Zhang T*,Zhang Y*. 2023. An efficient CRISPR–Cas12a promoter editing system for crop improvement. Nature Plants,9: 588-604.
4.Liu S, Sretenovic S, Fan T, Cheng Y, Li G, Qi A, Tang X, Xu Y, Guo W, Zhong Z, He Y, Liang Y, Han Q, Zheng X, Gu X, Qi Y*,Zhang Y*. 2022. Hypercompact CRISPR-Cas12j2 (CasΦ) enables genome editing, gene activation, and epigenome editing in plants. Plant Commun, 3: 100453.
5.Wu Y, Ren Q, Zhong Z, Liu G, Han Y, Bao Y, Liu L, Xiang S, Liu S, Tang X, Zhou J, Zheng X, Sretenovic S, Zhang T*, Qi Y*,Zhang Y*. 2022. Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice. Plant Biotechnol J, 20: 1670-1682.
6.Wu Y, Ren Q, Zhong Z, Liu G, Han Y, Bao Y, Liu L, Xiang S, Liu S, Tang X, Zhou J, Zheng X, Sretenovic S, Zhang T*, Qi Y*,Zhang Y*. 2022. Genome-wide analyses of PAM-relaxed Cas9 genome editors reveal substantial off-target effects by ABE8e in rice. Plant Biotechnology Journal, 10.1111/pbi.13838.
7.Zhou J, Zhang R, Jia X, Tang X, Guo Y, Yang H, Zheng X, Qian Q*, Qi Y*,Zhang Y*. 2022. CRISPR-Cas9 mediated OsMIR168a knockout reveals its pleiotropy in rice. Plant Biotechnology Journal, 20: 310-322.
8.Wu Y, He Y, Sretenovic S, Liu S, Cheng Y, Han Y, Liu G, Bao Y, Fang Q, Zheng X, Zhou J, Qi Y*,Zhang Y*, Zhang T*. 2021. CRISPR-BETS: a base-editing design tool for generating stop codons. Plant Biotechnology Journal, 10.1111/pbi.13732.
9.Ren Q, Simon S, Liu S, Tang X, Huang L, He Y, Liu L, Guo Y, Zhong Z, Liu G, Cheng Y, Zheng X, Pan C, Yin D, Zhang Y, Li W, Qi W, Li C, Qi Y*,Zhang Y*. 2021. PAM-less plant genome editing using a CRISPR-SpRY toolbox. Nature Plants, 7: 25-33.
10.Zhou J, Yuan M, Zhao Y, Quan Q, Yu D, Yang H, Tang X, Xin X, Cai G, Qian Q, Qi Y*,Zhang Y*. 2021. Efficient deletion of multiple circle RNA loci by CRISPR-Cas9 reveals Os06circ02797 as a putative sponge for OsMIR408 in rice. Plant Biotechnology Journal, 19: 1240-1252.
11.Ren Q, Sretenovic S, Liu G, Zhong Z, Wang J, Huang L, Tang X, Guo Y, Liu L, Wu Y, Zhou J, Zhao Y, Yang H, He Y, Liu S, Yin D, Mayorga R, Zheng X, Zhang T*, Qi Y*,Zhang Y*. 2021. Improved plant cytosine base editors with high editing activity, purity, and specificity. Plant Biotechnology Journal, 10.1111/pbi.13635.
12.Zhang Y, Ren Q, Tang X, Liu S, Malzahn AA, Zhou J, Wang J, Yin D, Pan C, Yuan M, Huang L, Yang H, Zhao Y, Fang Q, Zheng X, Tian L, Cheng Y, Le Y, McCoy B, Franklin L, Selengut JD, Mount SM, Que Q,Zhang Y*, Qi Y*. 2021. Expanding the scope of plant genome engineering with Cas12a orthologs and highly multiplexable editing systems. Nature Communications, 12: 1944.
13.Tang X, Sretenovic S, Ren Q, Jia X, Li M, Fan T, Yin D, Xiang S, Guo Y, Liu L, Zheng X, Qi Y*,Zhang Y*. 2020. Plant prime editors enable precise gene editing in rice cells. Molecular Plant, doi:10.1016/j.molp.2020.03.010.
14.Ming M, Ren Q, Pan C, He Y, Zhang Y, Liu S, Zhong Z, Wang J, Malzahn A, Wu J, Zheng X,Zhang Y*, Qi Y*. 2020. CRISPR-Cas12b enables efficient plant genome engineering. Nature Plants, 6: 202-208. 10.1038/s41477-020-0614-6.
15.Zhong Z, Sretenovic S, Ren Q, Yang L, Bao Y, Qi C, Yuan M, He Y, Liu S, Liu X, Wang J, Huang L, Wang Y, Baby D, Wang D, Zhang T, Qi Y*,Zhang Y*. 2019. Improving plant genome editing with high-fidelity xCas9 and non-canonical PAM-targeting Cas9-NG. Molecular Plant, 12(7): 1027-1036.doi: 10.1016/j.molp.2019.03.011.
16.Tang X, Ren Q, Yang L, Bao Y, Zhong Z, He Y, Liu S, Qi C, Liu B, Wang Y, Sretenovic S, Zhang Y, Zheng X, Zhang T*, Qi Y*,Zhang Y*. 2019. Single transcript unit CRISPR 2.0 systems for robust Cas9 and Cas12a mediated plant genome editing. Plant Biotechnology Journal, 17(7): 1431-1445. doi: 10.1111/pbi.13068.
17.Zhou J, Xin X, He Y, Chen H, Li Q, Tang X, Zhong Z, Deng K, Zheng X, Akher SA, Cai G, Qi Y*,Zhang Y*. 2019. Multiplex QTL editing of grain-related genes improves yield in elite rice varieties. Plant Cell Reports, 38(4): 475-485. doi: 10.1007/s00299-018-2340-3.
18.Tang X, Liu G, Zhou J, Ren Q, You Q, Tian L, Xin X, Zhong Z, Liu B, Zheng X, Zhang D, Malzahn A, Gong Z, Qi Y*, Zhang T*,Zhang Y*. 2018. A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice. Genome Biology,19(1): 84. doi: 10.1186/s13059-018-1458-5.
19.Zhong Z, Zhang Y, You Q, Tang X, Ren Q, Liu S, Yang L, Wang Y, Liu X, Liu B, Zhang T, Zheng X, Le Y,Zhang Y*, Qi Y*. 2018. Plant genome editing using FnCpf1 and LbCpf1 nucleases at redefined and altered PAM sites.Molecular Plant,11(7): 999-1002. doi: 10.1016/ j.molp.2018.03.008.
20.Lowder LG, Zhou J, Zhang Y, Malzahn A, Zhong Z, Hsieh TF, Voytas DF,Zhang Y*, Qi Y*. 2018. Robust transcriptional activation in plants using multiplexed CRISPR-Act2.0 and mtale-act systems. Molecular Plant, 11(2): 245-256. doi: 10.1016/j.molp.2017.11.010.
21.Tang X, Lowder LG, Zhang T, Malzahn A, Zheng X, Voytas DF, Zhong Z, Chen Y, Ren Q, Li Q, Kirkland ER,Zhang Y*, Qi Y*. 2017. A CRISPR-Cpf1 system for efficient genome editing and transcriptional repression in plants. Nature Plants, 3: 17018. doi:10.1038/nplants.2017.18.
22.Zhou J, Deng K, Cheng Y, Zhong Z, Tian L, Tang X, Tang A, Zheng X, Zhang T, Qi Y*,Zhang Y*. 2017. CRISPR-Cas9 based genome editing reveals new insights into microRNA function and regulation in rice. Frontiers in Plant Science, 8: 1598. doi: 10.3389/fpls.2017.01598.
23.Tang X, Zheng X, Qi YP, Zhang D, Cheng Y, Tang A, Voytas DF*,Zhang Y*. 2016. A single transcript CRISPR-Cas9 system for efficient genome editing in plants.Molecular Plant, 9(7): 1088-1091. doi:10.1016/j.molp.2016.05.001.
24.Lowder LG, Zhang D, Baltes NJ, Paul JW 3rd, Tang X, Zheng X, Voytas DF, Hsieh TF,Zhang Y*, Qi Y*. 2015. A CRISPR/Cas9 toolbox for multiplexed plant genome editing and transcriptional regulation.Plant Physiology, 169(2): 971-985. doi: 10.1104/pp.15.00636.
25.Shan QW, Wang YP, Chen KL, Liang Z, Li J, Zhang Y, Zhang K, Liu JX, Voytas DF, Zheng XL,Zhang Y*, Gao CX*. 2013. Rapid and efficient gene modification in rice and Brachypodium using TALENs. Molecular Plant, 6(4): 1365-1368.doi: 10.1093/mp/sss162.
26.Zhang Y, Zhang F, Li XH, Christian M, Bogdanove AJ, Qi YP, Starker CG, Bogdanove AJ, Voytas DF. 2013.Transcription activator-like effector nucleases enable efficient plant genome engineering. Plant Physiology, 161(1):20-27.
27.Zhang Y, Liu ZH, Liu C, Yang ZJ, Deng KJ, Peng JH, Zhou JP, Li GR, Tang ZX, Ren ZL. 2008. Analysis of DNA methylation variation in wheat genetic background after alien chromatin introduction based on methylation-sensitive amplification polymorphism.Chinese Science Bulletin,53(1): 58-69.
地址:重庆市北碚区天生路2号西南大学必赢nn699net 邮编400716
E-mail:zhangyong916@swu.edu.cn
个人/团队主页
https://scholar.google.com/citations?user=U3PtmKoAAAAJ&hl=en