廖志华,男,汉族,1974年12月3日出生,四川宜宾人。西南大学必赢nn699net教授、博士生导师。从事植物天然产物合成生物学和代谢工程研究。主持国家级和省部级项目20多项;作为通讯作者在《Molecular Plant》《New Phytologist》《Organic Letters》《Journal of Experimental Botany》《ACS Synthetic Biology》《Food Chemistry》等发表SCI收录论文50余篇;授权发明专利12项;育成多个植物新品种;相关成果实现产业化开发;指导学生在国家级科技竞赛中获一等奖和二等奖;获西南大学优秀教学成果一等奖,重庆市二等奖,西南大学优秀教师,教育部霍英东教育基金会高校优秀青年教师奖;2010年和2019年入选“重庆市级人才”;2012年入选教育部“国家级青年人才”;;任西南大学-西藏农牧大学药用植物联合研发中心主任,重庆市甘薯研究中心副主任;重庆市科学技术研究院生物医药中心副主任(兼),重庆市遗传学会副秘书长,重庆市植物学会副理事长。
坚持四个面向,聚焦立德树人
联系方式
重庆市北碚区天生路1号西南大学必赢nn699net,邮编:400715
办公电话及传真:023-68367146;E-mail:zhliao@swu.edu.cn
教育经历
2001/09-2004/06,复旦大学,遗传学系,遗传学博士,导师:唐克轩教授
1998/09-2001/06,西南师范大学,必赢nn699net,植物学硕士,导师:谈锋教授
1994/09-1998/06,西南师范大学,生命科学系,生物学学士
工作经历
2011/07-,西南大学,必赢nn699net,博士生导师,教授
2004/07-,西南大学,必赢nn699net,硕士生导师,教授
2011/09-2012/09,The University of British Columbia, Visiting Scholar
期刊审稿
Nature Communications, Molecular Plant, New Phytologist, Journal of Experimental Botany, ACS Synthetic Biology, Phytochemistry, Journal of Natural Products, Plant and Cell Physiology, Planta, Physiologia Plantarum, Journal of Agricultural and Food Chemistry, Industrial Crops and Products, Plant Cell Reports, Frontiers in Plant Science, Scientific Reports, Biotechnology and Applied Biochemistry, Plant Cell Tissue and Organ Culture, Biologia, Biotechnology Letters, Biologia Plantarum, PLoS ONE等20余份期刊审稿人。
研究生招生/博士后招聘
植物学:博士研究生,硕士研究生;遗传学:硕士研究生。常年招聘生物学及相关专业博士后工作人员。
人才计划
☆ “重庆市级人才”,重庆市,2010年、2019年
☆ “国家级青年人才”,教育部,2012年
主持科研项目(在研)
1) 国家自然科学基金重点项目:托品烷生物碱生物合成途径的全面解析与代谢工程及合成生物学研究,2020-2023
2) 国家自然科学基金面上项目:低温诱导青蒿素生物合成的分子机制研究,2020-2023
3) 国家自然科学基金面上项目:莨菪碱转运分子机制与代谢工程研究,2018-2021
4) 国家转基因重大专项:作物抗病虫调控回路设计技术任务7,2019-2020
5) 第四次全国中药资源普查专项:曲水县和达孜县中藏药资源普查,2019-2021
6) 成都新尚集团:东莨菪碱相关技术成果. 作价入股. 2020
7) 苏州唐基生物科技有限公司:高含量青蒿品种选育,2019-2021
8) 上海交通大学:青蒿素生物合成途径重要基因克隆与鉴定,2019-2020
9) 西藏自治区重大科技专项课题3:喜马拉雅紫茉莉与甘青青兰种质创新与优质种苗培育技术研究,2019-2021
代表性研究论文
☆ Zhao TF, Li SQ, Wang J, Zhou Q, Yang CX, Bai F, Lan XZ, Chen M,Liao ZH*. Engineering Tropane Alkaloid Production Based on Metabolic Characterization of Ornithine Decarboxylase in Atropa belladonna.ACS Synthetic Biology. 2020. 5-Year IF 5.905
☆ Qiu F, Zeng JL, Wang J, Huang JP, Zhou W, Yang CX, Lan XZ, Chen M, Huang SX*, Kai GY*,Liao ZH*. Functional genomics analysis reveals two novel genes required for littorine biosynthesis.New Phytologist. 2019. 5-Year IF 8.344
☆ Xiang LE, Jian DQ, Zhang FY, Yang CX, Bai G, Lan XZ, Chen M, Tang KX,Liao ZH*. The cold-induced transcription factor bHLH112 promotes artemisinin biosynthesis indirectly via ERF1 in Artemisia annua.Journal of Experimental Botany. 2019. 5-Year IF 6.305
☆ Qiu F, Yang CX, Yuan LN, Xiang D, Lan XZ, Chen M,Liao ZH*. A Phenylpyruvic Acid Reductase Is Required for Biosynthesis of Tropane Alkaloids.Organic Letters. 2018. 5-Year IF 6.555
☆ Zhang FY, Xiang LE, Yu Q, Zhang HX, Zhang TX, Zeng JL, Geng C, Li L, Fu XQ, Shen Q, Yang CX, Lan XZ, Chen M, Tang KX*,Liao ZH*. ARTEMISININ BIOSYNTHESIS PROMOTING KINASE 1 positively regulates artemisinin biosynthesis through phosphorylating AabZIP1.Journal of Experimental Botany. 2018. 5-Year IF 6.305
☆ Zhang FY, Fu XQ, Lv ZY, Lu X, Shen Q, Zhang L, Zhu MM, Wang GF, Sun XF,Liao ZH*and Tang KX*. A Basic Leucine Zipper Transcription Factor, AabZIP1, Connects Abscisic Acid Signaling with Artemisinin Biosynthesis in Artemisia annua.Molecular Plant. 2015. 5-Year IF 10.682
近5年发表研究论文
1) Qiu F, Zeng JL, Wang J, Huang JP, Zhou W, Yang CX, Lan XZ, Chen M, Huang SX*, Kai GY*,Liao ZH*. Functional genomics analysis reveals two novel genes required for littorine biosynthesis.New Phytologist. 2020. 5-Year IF 8.344.
2) Zhao TF, Li SQ, Wang J, Zhou Q, Yang CX, Bai F, Lan XZ, Chen M,LiaoZH*. Engineering Tropane Alkaloid Production Based on Metabolic Characterization of Ornithine Decarboxylase in Atropa belladonna.ACS Synthetic Biology. 2020. 5-Year IF 5.905
3) Xiang LE, Jian DQ, Zhang FY, Yang CX, Bai G, Lan XZ, Chen M, Tang KX,Liao ZH*. The cold-induced transcription factor bHLH112 promotes artemisinin biosynthesis indirectly via ERF1 in Artemisia annua.Journal of Experimental Botany. 2019. 5-Year IF 6.305
4) Bai F, Li SQ, Yang CX, Zhao TF, Zhang TX, Lan XZ, Chen M,Liao ZH*. Overexpression of the AbSAUR1 gene enhanced biomass production and alkaloid yield in Atropa belladonna.Industrial Crops and Products. 2019. 5-Year IF 4.419
5) Zhang QZ, Wu NY, Jian DQ, Jiang RQ, Yang CX, Lan XZ, Chen M, Zhang FY*,Liao ZH*. Overexpression of AaPIF3 promotes artemisinin production in Artemisia annua.Industrial Crops and Products. 2019. 5-Year IF 4.419
6) Zhao TF, Wang CJ, Bai F, Li SQ, Yang CX, Zhang FY, Bai G, Chen M, Lan XZ, Liao ZH*. Metabolic Characterization of Hyoscyamus niger Ornithine Decarboxylase.Frontiers in Plant Science. 2019. 5-Year IF 4.855
7) Zhang TX, Gou YQ, Bai F, Chen M, Zhang FY*, Liao ZH*. AaPP2C1 negatively regulates the expression of genes involved in artemisinin biosynthesis through dephosphorylating AaAPK1.FEBS Letters. 2019. 5-Year IF 3.386
8) Pan ZJ, Sun YM, Zhang FY, Guo XB* andLiao ZH*. Effect of Thermal Processing on Carotenoids and Folate Changes in Six Varieties of Sweet Potato (Ipomoes batata L.).Foods. 2019 IF 3.011
9) Qiu F, Yang CX, Yuan LN, Xiang D, Lan XZ, Chen M,Liao ZH*. A Phenylpyruvic Acid Reductase Is Required for Biosynthesis of Tropane Alkaloids.Organic Letters. 2018. 5-Year IF 6.555
10) Zhang FY, Xiang LE, Yu Q, Zhang HX, Zhang TX, Zeng JL, Geng C, Li L, Fu XQ, Shen Q, Yang CX, Lan XZ, Chen M, Tang KX*,Liao ZH*. ARTEMISININ BIOSYNTHESIS PROMOTING KINASE 1 positively regulates artemisinin biosynthesis through phosphorylating AabZIP1.Journal of Experimental Botany. 2018. 5-Year IF 6.305
11) Gen C, Zhao TF, Yang CX, Zhang QZ, Bai F, Zeng JL, Zhang FY, Liu XQ, Lan XZ, Chen M,Liao ZH*. Metabolic characterization of Hyoscyamus niger root-specific putrescine N-methyltransferase.Plant Physiology and Biochemistry. 2018. 5-Year IF 3.607
12) Zhang FY, Liu WH, Xia J, Zeng JL, Xiang LE, Zhu SQ, Zheng QM, Xie H, Yang CX, Chen M,Liao ZH*. Molecular Characterization of the 1-Deoxy-D-Xylulose 5-Phosphate Synthase Gene Family in Artemisia annua.Frontiers in Plant Science. 2018. 5-Year IF 4.855
13) Lan XZ,ZengJL,LiuK,ZhangFY,BaiG,ChenM, Liao ZH*, Huang LQ*. Comparison of two hyoscyamine 6β-hydroxylases in engineering scopolamine biosynthesis in root cultures of Scopolia lurida.Biochemical and Biophysical Research Communications. 2018. 5-Year IF 2.550
14) Liu XQ, Xiang M, Fang YF, Yang CX, Zeng LJ, Zhang QT, Chen M* andLiao ZH*. A Root-Preferential DFR-Like Gene Encoding Dihydrokaempferol Reductase Involved in Anthocyanin Biosynthesis of Purple-Fleshed Sweet Potato.Frontiers in Plant Science. 2017. 5-Year IF 4.855
15) Zhao KH, Zeng JL, Zhao TF, Zhang HX, Qiu F, Yang CX, Zeng LJ, Liu XQ, Chen M, Lan XZ*,Liao ZH*. Enhancing Tropane Alkaloid Production Based on the Functional Identification of Tropine-Forming Reductase in Scopolia lurida, a Tibetan Medicinal Plant.Frontiers in Plant Science. 2017. 5-Year IF 4.855
16) Liu WH, Wang HY, Chen YP, Zhu SQ, Chen M, Lan XZ, Chen GP* andLiao ZH*. Cold stress improves the production of artemisinin depending on the increase in endogenous jasmonate.Biotechnology and Applied Biochemistry. 2017. 5-Year IF 1.498.Cover Paper
17) Wang HY, Liu WH, Qiu F, Chen YP, Zhang FY, Lan XZ, Chen M, Zhang HX* andLiao ZH*. Molecular cloning and characterization of the promoter of aldehyde dehydrogenase gene from Artemisia annua.Biotechnology and Applied Biochemistry. 2017. 5-Year IF 1.498
18) Ge JQ, Hu YJ, Wang HX, Huang YS, Zhang P*,Liao ZH*and Chen M*. Profiling of anthocyanins in transgenic purple-fleshed sweet potatoes by HPLC-MS/MS.Journal of The Science of Food and Agriculture. 2017. 5-Year IF 2.733
19) Hu YJ, Deng LQ, Chen JW, Zhou SY, Liu S, Fu YF, Yang CX,Liao ZH*, Chen M*. An analytical pipeline to compare and characterise the anthocyanin antioxidant activities of purple sweet potato cultivars.Food Chemistry. 2016. 5-Year IF 5.399
Qiang W, Xia K, Zhang QZ, Zeng JL, Huang YS, Yang CX, Chen M, Liu XQ, Lan XZ,Liao ZH*. Functional characterisation of a tropine-forming reductase gene from Brugmansia arborea, a woody plant species producing tropane alkaloids.Phytochemistry. 2016. 5-Year IF 3.272
20) Xia K, Liu XQ, Zhang QZ, Qiang W, Guo JJ, Lan XZ, Chen M, Liao ZH*. Promoting scopolamine biosynthesis in transgenic Atropa belladonna plants with pmt and h6h overexpression under field conditions.Plant Physiology and Biochemistry. 2016. 5-Year IF 3.607
21) Zhang FY, Fu XQ, Lv ZY, Lu X, Shen Q, Zhang LD, Zhu MM, Wang GF, Sun XF,Liao ZH*, Tang KX*. A Basic Leucine Zipper Transcription Factor, AabZIP1, Connects Abscisic Acid Signaling with Artemisinin Biosynthesis in Artemisia annua.Molecular Plant. 2015. 5-Year IF 10.682
22) Xiang LE, Zhu SQ, Zhao TF, Zhang M, Liu WH, Chen M, Lan XQ,Liao ZH*. Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment.Plant Growth Regulation. 2015. 5-Year IF 2.758
23) Liu WH, Zhao TF, Wang HY, Zeng JL, Xiang LE, Zhu SQ, Chen M, Lan XZ, Liu XQ,Liao ZH*. Reference gene selection in Artemisia annua L., a plant species producing anti-malarial artemisinin.Plant Cell Tissue and Organ Culture. 2015. 5-Year IF 2.232
24) Yuan Y, Liu WH, Zhang QZ, Xiang LE, Liu XQ, Chen M, Lin Z, Wang Q,Liao ZH*. Overexpression of artemisinic aldehyde Δ11 (13) reductase gene enhanced artemisinin and its relative metabolite biosynthesis in transgenic Artemisia annua L.Biotechnology and Applied Biochemistry. 2015. 5-Year IF 1.498
奖励
1)廖志华,霍英东教育基金会高校优秀青年教师奖,教育部,三等奖,2010
2)廖志华(第二获奖人),重庆市优秀教学成果奖,重庆市,二等奖,2009
3)廖志华(第三获奖人),西藏鬼臼毒素植物资源与生物技术研究,西藏自治区,科学技术二等奖,2012年
授权专利
1)廖志华,陈敏,杨春贤,赵腾飞,强玮. 颠茄钙调蛋白AbCaM1基因及其重组植物表达载体和应用. ZL2017113103160.授权,转让
2)廖志华,陈敏,杨春贤,邱飞,强玮. 颠茄WRKY类转录因子基因及其重组植物表达载体和应用. ZL201711310317.5.授权,转让
3)廖志华,陈敏,杨春贤,兰小中,孙敏,傅玉凡,张启堂. 利用基因工程技术培育托品托品烷类生物碱高产的颠茄及方法. ZL200510057141.8.授权,转让
4)廖志华,陈敏,谌容. 青蒿HDR蛋白编码序列. ZL200610054600.1.授权
5)廖志华,陈敏,谌容. 携带质体转运肽的法呢基焦磷酸合成酶融合基因及应用. ZL200610054599.2.授权
6)廖志华,陈敏,谌容. 携带质体转运肽的紫槐二烯合成酶融合基因及应用. ZL200610095202.4.授权
7)廖志华,陈敏,谌容. 萝芙木色氨酸脱羧酶蛋白编码序列.ZL200610095201.X.授权
主持科研项目(结题)
1) 国家自然科学基金:WRKY类转录因子在托品烷类生物碱生物合成中的调控作用研究,2014-2017
2) 国家自然科学基金:MVA和MEP途径遗传改造对青蒿素生物合成的影响,2011-2013
3) 国家自然科学基金:紫杉醇前体依赖于MEP途径合成的分子调控机理,2008-2010
4) 国家自然科学基金:银杏内酯前体生物合成途径中关键酶基因的克隆与功能分析,2006-2008
5) 国家863计划:东莨菪碱植物代谢产物生物反应器研制,2011-2015
6) 国家863计划:甘薯营养品质的遗传改良,2011-2015
7) 国家863计划:转FPS/DXR基因青蒿研究与转基因新品系培育,2010-2011
8) 重庆市科技攻关项目:甘薯转基因关键技术研究与应用,2010-2012
9) 重庆市自然科学基金重点项目:甘薯多酚氧化酶基因鉴定与抗褐化甘薯种质创新,2005-2007
10) 重庆市高校优秀青年人才资助计划:颠茄代谢工程研究与新品系培育,2011-2013
11) 中央高校基本科研业务费专项:西南大学创新团队-青蒿前体生物合成功能基因组学研究,2013-2015
指导学生获奖
1) 谌容、彭梅芳.萝芙木毛状根培养体系的建立和TIAs生物合成途径中关键酶基因的克隆与分析. 第九届挑战杯中国大学生科技竞赛全国一等奖. 2005年. 指导教师:廖志华
2) 曾俊岚、刘坷. 东莨菪碱合成限速酶基因和根系发育基因对托品烷生物碱合成的影响.第十五届挑战杯全国大学生课外科技作品竞赛重庆赛区特等奖. 2017年. 指导教师:廖志华
3) 刘坷、康志鑫. 鸟氨酸脱羧酶在托品烷生物碱合成中的功能研究. 2017年. 第一届全国大学生生命科学竞赛二等奖. 指导教师:廖志华